MYASTHENIA GRAVIS – GENERAL INFORMATION
Friday, May 15th, 2009The disorder usually begins in early adult life but may occur in children or in the elderly. It is often associated with other disorders, such as overactivity of the thyroid gland, diabetes, rheumatoid arthritis and other diseases.
The muscles become progressively weaker as they are used during the day and seem to recover overnight.
When we wish to use muscles, we send an impulse down the nerve to the muscle. At the nerve ending, a chemical, acetylcholine, is released and this stimulates the muscle to contract.
In myasthenia gravis, the supply of acetylcholine appears to run out with repeated use and the muscles become progressively weaker. The supply appears to build up with rest. Sometimes the muscle become permanently weak.
The drug neostigmine, or its derivatives, is used to overcome the lack of acetylcholine and, if given several times a day, can control the symptoms. The disease tends to remit and relapse but, occasionally, is rapidly progressive and may be fatal.
In some, removal of the thymus does seem to lead to remission but the operation is still controversial.
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