There are three main types of oestrogen produced by the body; oestrone, oestradiol and oestriol (see pages 171—2). They influence the functioning of various parts of a woman’s body:
the growth and development of the uterus and its lining (the endometrium)
the thickness and tone of the vaginal lining and the vagina’s production of secretions
the fullness, tone and secretions of the vulva, cervix and urethra
bone growth
temperament and sexual interest, by an action on the brain
many other body tissues such as the skin, heart, blood vessels, breasts, liver and joints
OESTROGENS USED IN HRT The main reasons for giving oestrogen at and after menopause are to relieve distressing or debilitating symptoms and to reduce future risk of fractures and heart disease. In general, ‘natural’ oestrogens are the preferred form of oestrogen in HRT, and a number of alternatives are available.
Severe symptoms are especially likely in women who have had a surgical menopause, and this partly accounts for their relatively high use of HRT. They are also more likely to seek treatment than women who have had a natural menopause. Women taking oestrogen alone tend to stay on their hormone therapy for longer than women taking oestrogen plus progestogen (with or without testosterone), perhaps because they do not experience the unwanted side effects sometimes associated with the progestogens. In recent years Estigyn has fallen from favour among specialist menopause clinicians because of increased stimulation of liver-derived proteins that may result in high blood pressure, fluid build-up, and an increase in clotting factors. In other words Estigyn, being synthetic, is capable of ‘revving up’ the liver far more than the natural oestrogens. A major reason why synthetic hormones are more likely to cause side effects than natural hormones is that the body takes longer to break them down, providing more time for them to act on various tissues. This effect may be enhanced with age, which is why doctors prefer not to use them in the older woman.
The natural oestrogens used in HRT formulations tend to have fewer effects on liver function (and consequently on blood pressure and blood clotting) than the synthetic oestrogens. They may be considered suitable if you are one of those women for whom the synthetic hormones of the Pill were not considered safe.
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